Article
Racial disparity in breast cancer and functional germ line mutation in galectin-3 (rs4644): a pilot study.
Cancer research - 15 Dec 2008
Balan Vitaly, Nangia-Makker Pratima, Schwartz Ann G, Jung Young Suk, Tait Larry, Hogan Victor, Raz Tirza, Wang Yi, Yang Zeng Quan, Wu Gen Sheng, Guo Yongjun, Li Huixiang, Abrams Judith, Couch Fergus J, Lingle Wilma L, Lloyd Ricardo V, Ethier Stephen P, Tainsky Michael A, Raz Avraham
Abstract excerpt
For reasons largely unknown, Caucasian women are at a significantly higher risk of developing breast cancer than Asian women. Over a decade ago, mutations in BRCA1/2 were identified as genetic risk factors; however, the discovery of additional breast cancer genes and genes contributing to racial disparities are lacking. We report a functional germline mutation (polymorphism) in the galectin-3 gene at position 191...
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