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Article

Mechanisms and functional consequences of PDEF protein expression loss during prostate cancer progression

28 Mar 2011

Abstract excerpt

BACKGROUND: Ets is a large family of transcriptional regulators with functions in most biological processes. While the Ets family gene, prostate-derived epithelial factor (PDEF), is expressed in epithelial tissues, PDEF protein expression has been found to be reduced or lost during cancer progression. The goal of this study was to examine the mechanism for and biologic impact of altered PDEF expression in...

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PMID: 21446014
DOI: 10.1002/pros.21389

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