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Article

Prostate-Derived Ets Factor (PDEF) Inhibits Metastasis by Inducing Epithelial/Luminal Phenotype in Prostate Cancer Cells.

Molecular cancer research : MCR - 1 Sept 2018

Wang Fengtian, Koul Sweaty, Shanmugam Prakash S T, Dong Qin, Koul Hari K

Abstract excerpt

Metastasis is the primary cause of prostate cancer morbidity and mortality. Our previous studies revealed that Sam pointed domain ETS transcription factor, a.k.a. prostate-derived ETS factor (SPDEF/PDEF), inhibits prostate cancer metastasis. However, the mechanism is still unclear. In this study, using microarray and gene set enrichment analysis, we discovered that PDEF upregulated epithelial/luminal...

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Source

Identifiers

PMID: 29848555
DOI: 10.1158/1541-7786.MCR-18-0010

Genes

SPDEF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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