Article
Identification and characterization of host-protective T-cell epitopes of a major surface glycoprotein (gp63) from Leishmania major.
Immunology - 1 Jan 1991
Yang D M, Rogers M V, Liew F Y
Abstract excerpt
By using a series of overlapping synthetic peptides that cover more than 75% of the amino acid sequence of the major surface glycoprotein (gp63) from Leishmania major, 11 T-cell epitopes in CBA and BALB/c mice have been identified. Six of the peptides were recognized by T cells of CBA mice recovered from L. major infection, while one was recognized by the T cells from BALB/c mice recovered from the infection...
Topics
- Amino Acid Sequence
- Animals
- Antigens, Protozoan
- Host-Parasite Interactions
- Hypersensitivity, Delayed
- Immunity, Active
- Leishmania tropica
- Leishmaniasis
- Lymphokines
- Metalloendopeptidases
- Mice