Article
Protection against murine listeriosis by oral vaccination with recombinant Salmonella expressing hybrid Yersinia type III proteins.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2001
Rüssmann H, Igwe E I, Sauer J, Hardt W D, Bubert A, Geginat G
Abstract excerpt
In the present study, we have investigated the possibility to engage the Yersinia outer protein E (YopE) as a carrier molecule for heterologous Ag delivery by the type III secretion system of Salmonella typhimurium. Defined secretion and translocation domains of YopE were fused to the immunodominant T cell Ags listeriolysin O and p60 of Listeria monocytogenes. In vitro experiments showed that S. typhimurium...
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