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Article

Direct detection of single-nucleotide polymorphisms in bacterial DNA by SNPtrap.

Preparative biochemistry & biotechnology - 1 Jan 2011

Grønlund Hugo, Moen Birgitte, Hoorfar Jeffrey, Radstrøm Peter, Malorny Burkhard, Rudi Knut

Abstract excerpt

A major challenge with single-nucleotide polymorphism (SNP) fingerprinting of bacteria and higher organisms is the combination of genome-wide screenings with the potential of multiplexing and accurate SNP detection. Single-nucleotide extension by the minisequencing principle represents a technology that both is highly accurate and enables multiplexing. A current bottleneck for direct genome analyses by...

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PMID: 21442552
DOI: 10.1080/10826068.2011.547366

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