Characterization of the binucleated giant cells generated in the autologous mixed leucocyte reaction from patients with rheumatoid arthritis.

doi:10.1111/j.1365-2249.1990.tb03330.x

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Article

Characterization of the binucleated giant cells generated in the autologous mixed leucocyte reaction from patients with rheumatoid arthritis.

Clinical and experimental immunology - 1 Aug 1990

Goto M, Tsai V, Zvaifler N J

Abstract excerpt

Binucleated giant cells several times larger than lymphocytes or monocytes were generated in an autologous mixed leucocyte reaction (AMLR) independent of DNA synthesis in patients with rheumatoid arthritis (RA). The AMLR giant cells with multiple cytoplasmic granules were non-specific esterase-st...

Topics

Adolescent
Adult
Aged
Aging
Antibodies, Monoclonal
Arthritis, Rheumatoid
Cells, Cultured
Cytotoxicity Tests, Immunologic
Female
Giant Cells
Humans
Killer Cells, Natural

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukocyte Count

Lymphocyte Activation

Lymphocyte Culture Test, Mixed

Male

Middle Aged

Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 2143708
DOI: 10.1111/j.1365-2249.1990.tb03330.x
PMCID: PMC1535067

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2143708-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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