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Article

<i>RUNX1</i> Translocations and Fusion Genes in Malignant Hemopathies

21 Dec 2010

Abstract excerpt

The RUNX1 gene, located in chromosome 21q22, is crucial for the establishment of definitive hematopoiesis and the generation of hematopoietic stem cells in the embryo. It contains a 'Runt homology domain' as well as transcription activation and inhibition domains. RUNX1 can act as activator or repressor of target gene expression depending upon the large number of transcription factors, coactivators and...

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Identifiers

PMID: 21174539
DOI: 10.2217/fon.10.158

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