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Article

2,4,5-Trisubstituted thiazole derivatives: a novel and potent class of non-nucleoside inhibitors of wild type and mutant HIV-1 reverse transcriptase.

European journal of medicinal chemistry - 6 Oct 2014

Xu Zhongliang, Ba Mingyu, Zhou Hua, Cao Yingli, Tang Chaojun, Yang Ying, He Ricai, Liang Yu, Zhang Xuemei, Li Zhenzhong, Zhu Lihong, Guo Ying, Guo Changbin

Abstract excerpt

Novel 2,4,5-trisubstituted thiazole derivatives (TSTs) were designed and synthesized as HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs). Among the thirty-eight synthesized target compounds, thirty TSTs showed potent inhibition against HIV-1 replication in wild type HIV-1 at submicromolar concentrations (from 0.046 to 9.59 μM). Compounds 21, 23 and 24 were also tested on seven NNRTI-resistant HIV-1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25072874
DOI: 10.1016/j.ejmech.2014.07.072

Genes

TST

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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