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Article

Blood ties: chimerism can mask twin discordance in high-throughput sequencing.

Twin research and human genetics : the official journal of the International Society for Twin Studies - 1 Apr 2011

Erlich Yaniv

Abstract excerpt

Twin studies have long provided a means to separate the contributions of genetic and environmental factors. A recent pioneering report by Baranzini et al. presented an analysis of the complete genomes and epigenomes of a monozygotic (MZ) twin pair discordant for multiple sclerosis. This failed to find any difference between the twins, raising doubts regarding the value of whole-genome twin studies for defining...

Topics

Child
Chimerism
DNA
Diseases in Twins
Female
Genetic Predisposition to Disease
Genome, Human
Genotype
Humans
Multiple Sclerosis
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Risk Factors

Sequence Analysis, DNA

Twins, Dizygotic

Twins, Monozygotic

Source

Identifiers

PMID: 21425895
DOI: 10.1375/twin.14.2.137

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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