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Article

How Ancestry Influences the Chances of Finding Unrelated Donors: An Investigation in Admixed Brazilians.

Frontiers in immunology - 1 Jan 2020

Nunes Kelly, Aguiar Vitor R C, Silva Márcio, Sena Alexandre C, de Oliveira Danielli C M, Dinardo Carla L, Kehdy Fernanda S G, Tarazona-Santos Eduardo, Rocha Vanderson G, Carneiro-Proietti Anna Barbara F, Loureiro Paula, Flor-Park Miriam V, Maximo Claudia, Kelly Shannon, Custer Brian, Weir Bruce S, Sabino Ester C, Porto Luís Cristóvão, Meyer Diogo

Abstract excerpt

A match of HLA loci between patients and donors is critical for successful hematopoietic stem cell transplantation. However, the extreme polymorphism of HLA loci - an outcome of millions of years of natural selection - reduces the chances that two individuals will carry identical combinations of multilocus HLA genotypes. Further, HLA variability is not homogeneously distributed throughout the world: African...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33240273
DOI: 10.3389/fimmu.2020.584950
PMCID: PMC7677137

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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