Article
Origins of Cdx1 regulatory elements suggest roles in vertebrate evolution.
The International journal of developmental biology - 1 Jan 2011
Gaunt Stephen J, Paul Yu-Lee
Abstract excerpt
Cdx1, an upstream regulator of Hox genes, is best characterized for its homeotic effects upon the developing axial skeleton, particularly in the neck. It responds to retinoic acid (RA) in both mouse embryos and embryonal carcinoma (EC) cells. By use of beta-galactosidase chemiluminescence, we show that a mouse Cdx1/lacZ reporter expressed in P19 EC cells responds to RA by the combined activities of an intron...
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