Article
The most common type of FTLD-FUS (aFTLD-U) is associated with a distinct clinical form of frontotemporal dementia but is not related to mutations in the FUS gene.
Acta neuropathologica - 1 Jul 2011
Snowden Julie S, Hu Quan, Rollinson Sara, Halliwell Nicola, Robinson Andrew, Davidson Yvonne S, Momeni Parastoo, Baborie Atik, Griffiths Timothy D, Jaros Evelyn, Perry Robert H, Richardson Anna, Pickering-Brown Stuart M, Neary David, Mann David M A
Abstract excerpt
Frontotemporal lobar degeneration (FTLD) is clinically, pathologically and genetically heterogeneous. Recent descriptions of a pathological sub-type that is ubiquitin positive, TDP-43 negative and immunostains positive for the Fused in Sarcoma protein (FUS) raises the question whether it is associated with a distinct clinical phenotype identifiable on clinical grounds, and whether mutations in the Fused in...
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