Article
Yeast prion protein derivative defective in aggregate shearing and production of new 'seeds'.
The EMBO journal - 3 Dec 2001
Borchsenius A S, Wegrzyn R D, Newnam G P, Inge-Vechtomov S G, Chernoff Y O
Abstract excerpt
According to the nucleated polymerization model, in vivo prion proliferation occurs via dissociation (shearing) of the huge prion polymers into smaller oligomeric 'seeds', initiating new rounds of prion replication. Here, we identify the deletion derivative of yeast prion protein Sup35 (Sup35-Delta22/69) that is specifically defective in aggregate shearing and 'seed' production. This derivative, [PSI+],...
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