Article
Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study.
Human molecular genetics - 1 Jun 2011
Fox Ervin R, Young J Hunter, Li Yali, Dreisbach Albert W, Keating Brendan J, Musani Solomon K, Liu Kiang, Morrison Alanna C, Ganesh Santhi, Kutlar Abdullah, Ramachandran Vasan S, Polak Josef F, Fabsitz Richard R, Dries Daniel L, Farlow Deborah N, Redline Susan, Adeyemo Adebowale, Hirschorn Joel N, Sun Yan V, Wyatt Sharon B, Penman Alan D, Palmas Walter, Rotter Jerome I, Townsend Raymond R, Doumatey Ayo P, Tayo Bamidele O, Mosley Thomas H, Lyon Helen N, Kang Sun J, Rotimi Charles N, Cooper Richard S, Franceschini Nora, Curb J David, Martin Lisa W, Eaton Charles B, Kardia Sharon L R, Taylor Herman A, Caulfield Mark J, Ehret Georg B, Johnson Toby, Chakravarti Aravinda, Zhu Xiaofeng, Levy Daniel
Abstract excerpt
The prevalence of hypertension in African Americans (AAs) is higher than in other US groups; yet, few have performed genome-wide association studies (GWASs) in AA. Among people of European descent, GWASs have identified genetic variants at 13 loci that are associated with blood pressure. It is unknown if these variants confer susceptibility in people of African ancestry. Here, we examined genome-wide and...
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