Article
The impact of epithelial biomarkers, local immune response and human papillomavirus genotype in the regression of cervical intraepithelial neoplasia grades 2-3.
Journal of clinical pathology - 1 Apr 2011
Ovestad Irene Tveiterås, Gudlaugsson Einar, Skaland Ivar, Malpica Anais, Munk Ane Cecilie, Janssen Emiel A M, Baak Jan P
Abstract excerpt
BACKGROUND AND AIMS: 15-30% of cases of cervical intraepithelial neoplasia grades 2-3 (CIN2-3) detected in punch biopsies regress spontaneously (ie, show CIN1 or less in the follow-up cone). Epithelial retinoblastoma protein (pRb), tumour suppressor protein (p53), HPV genotype and immunoreactive cells have been reported to be helpful in predicting regression but their interaction in regression prediction is...
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