Article
Regression of low-grade cervical intraepithelial neoplasia in patients with HLA-DRB1*13 genotype.
Obstetrics and gynecology - 1 Oct 2004
Sastre-Garau Xavier, Cartier Isabelle, Jourdan-Da Silva Nathalie, De Crémoux Patricia, Lepage Virginia, Charron Dominique
Abstract excerpt
OBJECTIVE: The human leukocyte antigen (HLA)-DRB1*13 allele frequency is lower in women with cervical carcinoma than in the general population, suggesting that this allele could exert a protective effect against progression of cervical intraepithelial neoplasia (CIN) associated with human papillomaviruses (HPV). To test this hypothesis, we designed a prospective study of low-grade CIN (CIN1) and analyzed the...
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