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Article

Crystal structure of E339K mutated human glucokinase reveals changes in the ATP binding site.

FEBS letters - 20 Apr 2011

Liu Qiang, Shen Yunfeng, Liu Sanling, Weng Jianping, Liu Jinsong

Abstract excerpt

Human glucokinase (GK) plays an important role in glucose homeostasis. An E339K mutation in GK was recently found to be associated with hyperglycemia. It showed lower enzyme activity and impaired protein stability compared to the wild-type enzyme. Here, we present the crystal structure of E339K GK in complex with glucose. This mutation results in a conformational change of His416, spatially interfering with...

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Identifiers

PMID: 21420961
DOI: 10.1016/j.febslet.2011.03.026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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