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Identification and analysis of novel R308K mutation in glucokinase of type 2 diabetic patient and its kinetic correlation.

Biotechnology and applied biochemistry - 1 Jan 2000

Yellapu Nanda Kumar, Valasani Koteswara Rao, Pasupuleti Santhosh Kumar, Gopal Sowjenya, Potukuchi Venkata Gurunadha Krishna Sarma, Matcha Bhaskar

Abstract excerpt

Glucokinase (GK) plays a critical role in glucose homeostasis and the mutations in GK gene result in pathogenic complications known as Maturity Onset Diabetes of the Young 2, an autosomal dominant form of diabetic condition. In the present study, GK was purified from human liver tissue and the pure enzyme showed single band in SDS-PAGE with a molecular weight of 50 kDa. The kinetics of pure GK showed enzyme...

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PMID: 24447076
DOI: 10.1002/bab.1209

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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