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Article

Structure-function analysis of the alpha5 and the alpha13 helices of human glucokinase: description of two novel activating mutations.

Protein science : a publication of the Protein Society - 1 Aug 2005

Pedelini Leda, Garcia-Gimeno Maria Adelaida, Marina Alberto, Gomez-Zumaquero Juan M, Rodriguez-Bada Pablo, López-Enriquez Soledad, Soriguer Federico C, Cuesta-Muñoz Antonio L, Sanz Pascual

Abstract excerpt

It was recently described that the alpha5 and the alpha13 helices of human pancreatic glucokinase play a major role in the allosteric regulation of the enzyme. In order to understand the structural importance of these helices, we have performed site-directed mutagenesis to generate glucokinase derivatives with altered residues. We have analyzed the kinetic parameters of these mutated forms and compared them with...

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Identifiers

PMID: 15987895
DOI: 10.1110/ps.051485205
PMCID: PMC2279319

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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