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Imatinib induces autophagy through<i>BECLIN‐1</i>and<i>ATG5</i>genes in chronic myeloid leukemia cells

1 Mar 2011

Abstract excerpt

Imatinib is a chemotherapeutic drug used for the treatment of chronic myeloid leukemia (CML). Recent data showed imatinib-induced cell death in various types of cancers. Autophagy is the physiological process in which cellular components are broken down by the lysosomal activation. In this study, we aimed to examine the effects of imatinib on autophagy in addition to apoptosis in CML cells. Results suggested that...

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PMID: 21418740
DOI: 10.1179/102453311x12902908412039

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