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Article

The core autophagy protein ATG4B is a potential biomarker and therapeutic target in CML stem/progenitor cells

23 Apr 2014

Abstract excerpt

Previous studies demonstrated that imatinib mesylate (IM) induces autophagy in chronic myeloid leukemia (CML) and that this process is critical to cell survival upon therapy. However, it is not known if the autophagic process differs at basal levels between CML patients and healthy individuals and if pretreatment CML cells harbor unique autophagy characteristics that could predict patients' clinical outcomes. We...

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PMID: 24755409
DOI: 10.1182/blood-2013-07-516807

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