Article

The c-KIT Exon 11 Deletions Cause Resistant to Imatinib Treatment of GISTs through Induction of ULK1-SRC related Autophagy

2020-04-10

Abstract excerpt

<h4>Background: </h4> Exon 11 deletion of c-KIT is the common mutation site with the worst prognosis of gastrointestinal stromal tumors (GISTs). Autophagy has shown to have both protumor and antitumor functions and protect GIST cells from imatinib (IM)-induced apoptosis. In this study, we aimed to explore whether c-KIT exon 11 deletions of GISTs drive refractory to IM treatment through regulation of autophagy. <h4...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 154efa8c-df2d-5172-be54-05f7657189d1
DOI: 10.21203/rs.3.rs-22031/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The c-KIT Exon 11 Deletions Cause Resistant to Imatinib Treatment of GISTs through Induction of ULK1-SRC related AutophagyDOI 10.21203/rs.3.rs-22031/v1Read

MTOR inhibition enhances NVP-AUY922-induced autophagy-mediated KIT degradation and cytotoxicity in imatinib-resistant gastrointestinal stromal tumors.Semantic proximity Read

Imatinib induces autophagy through<i>BECLIN‐1</i>and<i>ATG5</i>genes in chronic myeloid leukemia cellsSemantic proximity Read

KIT Exon 11 Codons 557-558 Deletion Mutation Promotes Liver Metastasis Through the CXCL12/CXCR4 Axis in Gastrointestinal Stromal Tumors.Semantic proximity Read

New Mechanisms of mTOR Pathway Activation in KIT-mutant Malignant GISTs.Semantic proximity Read

Neoadjuvant Imatinib in Locally Advanced Gastrointestinal stromal Tumours, Will Kit Mutation Analysis Be a Pathfinder?Semantic proximity Read

Targeting the translational machinery in gastrointestinal stromal tumors (GIST) – a new therapeutic vulnerabilitySemantic proximity Read

LncRNA OIP5-AS1 Promotes the Autophagy-Related Imatinib Resistance in Chronic Myeloid Leukemia Cells by Regulating miR-30e-5p/ATG12 AxisSemantic proximity Read

MicroRNA-30a targets BECLIN-1 to inactivate autophagy and sensitizes gastrointestinal stromal tumor cells to imatinibSemantic proximity Read

Targeting the translational machinery in gastrointestinal stromal tumors (GIST): a new therapeutic vulnerability.Semantic proximity Read

Breaking the redundancy: TAZ outperforms YAP1 in GIST progressionSemantic proximity Read

In vivo effect of imatinib on progression of cecal GIST-like tumors in exon 17-type c-kit knock-in mice.Semantic proximity Read

BPR1J373, a novel multitargeted kinase inhibitor, effectively suppresses the growth of gastrointestinal stromal tumor.Semantic proximity Read