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Article

TPH2 G/T polymorphism is associated with hyperphagia, IQ, and internalizing problems in Prader-Willi syndrome.

Journal of child psychology and psychiatry, and allied disciplines - 1 May 2011

Dykens Elisabeth M, Roof Elizabeth, Bittel Douglas, Butler Merlin G

Abstract excerpt

BACKGROUND: Prader-Willi syndrome (PWS) is a genetic, neurodevelopmental disorder characterized by intellectual disabilities, growth hormone dysregulation, hyperphagia, increased risks of morbid obesity, compulsive behaviors, and irritability. As aberrant serotonergic functioning is strongly implicated in PWS, we examined associations between the PWS phenotype and polymorphisms in tryptophan hydroxylase 2 (TPH2),...

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Identifiers

PMID: 21418060
DOI: 10.1111/j.1469-7610.2011.02365.x
PMCID: PMC3353323

Genes

TPH2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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