Article
Embryonic exposure to diclofenac disturbs actin organization and leads to myofibril misalignment.
Birth defects research. Part B, Developmental and reproductive toxicology - 1 Apr 2011
Chen Ying-Hsin, Chang Chao-Yuan, Wang Yun-Hsin, Wen Chi-Chung, Chen Yun-Chen, Hu Sheng-Chuan, Yu Dah-Shyong, Chen Yau-Hung
Abstract excerpt
The objective of this study was to investigate the embryotoxicity of diclofenac. Zebrafish (Danio rerio) embryos at 12 hpf were treated with different dosages of diclofenac (0-2,000 ppm) for different time courses (12-72 hr). Results showed no evident differences in survival rates or morphological changes between the mock-treated control (0 ppm) zebrafish embryos and those with 1-ppm diclofenac-exposure (12-24,...
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