Article
Divergent teratogenicity of agonists of retinoid X receptors in embryos of zebrafish (Danio rerio).
Ecotoxicology (London, England) - 1 Jul 2012
Shi Huahong, Zhu Pan, Sun Zhi, Yang Bo, Zheng Liang
Abstract excerpt
Zebrafish (Danio rerio) embryos were comparably exposed to seven known agonists of retinoid X receptors (RXRs) including two endogenous compounds (9-cis-retinoic acid and docosahexaenoic acid), four man-made selective ligands (LGD1069, SR11237, fluorobexarotene and CD3254), and a biocide (triphenyltin). The dominant phenotypes of malformation were sharp mouths and small caudal fins in 1 mg/L SR11237-treated group...
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