Article

Domoic acid disruption of neurodevelopment and behavior involves altered myelination in the spinal cord

2019-11-15

Abstract excerpt

<h4>ABSTRACT</h4> Harmful algal blooms (HABs) produce potent neurotoxins that threaten human health. Early life exposure to low levels of the HAB toxin domoic acid (DomA) produces long-lasting behavioral deficits, but the mechanisms involved are unknown. Using zebrafish, we investigated the developmental window of susceptibility to low doses of DomA and examined cellular and molecular targets. Larvae exposed to D...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 27c7f22e-3625-5708-b030-9623c8e50ef5
DOI: 10.1101/842294

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Domoic acid disruption of neurodevelopment and behavior involves altered myelination in the spinal cordDOI 10.1101/842294Read

Developmental exposure to domoic acid targets reticulospinal neurons and leads to aberrant myelination in the spinal cordSemantic proximity Read

Drosophila melanogaster as an indispensable model to decipher the mode of action of neurotoxic compoundsSemantic proximity Read

Toxicogenomic and phenotypic analyses of bisphenol-A early-life exposure toxicity in zebrafish.Semantic proximity Read

The cyanotoxin 2,4-DAB enhances mortality and causes behavioral and molecular dysfunctions associated with neurodegeneration in larval zebrafishSemantic proximity Read

Short-chain PFAS exposure alters embryonic development and behavior in zebrafishSemantic proximity Read

Assessment of developmental neurotoxicology-associated alterations in neuronal architecture and function using <i>Caenorhabditis elegans</i>Semantic proximity Read

The Cyanotoxin 2,4-DAB Reduces Viability and Causes Behavioral and Molecular Dysfunctions Associated with Neurodegeneration in Larval ZebrafishSemantic proximity Read

Altered behavioral performance and live imaging of circuit-specific neural deficiencies in a zebrafish model for psychomotor retardation.Semantic proximity Read

CNS Hypomyelination Disrupts Axonal Conduction and Behavior in Larval Zebrafish.Semantic proximity Read

Long-Term Neurotoxic Effects and Alzheimer’s Disease Risk of Early EHDPP Exposure in Zebrafish: Insights from Molecular Mechanisms to Adult PathologySemantic proximity Read

Systemic loss of Sarm1 protects Schwann cells from chemotoxicity by delaying axon degeneration.Semantic proximity Read

Editor's Highlight: Embryonic Exposure to the Environmental Neurotoxin BMAA Negatively Impacts Early Neuronal Development and Progression of Neurodegeneration in the Sod1-G93R Zebrafish Model of Amyotrophic Lateral Sclerosis.Semantic proximity Read