Article
Melanoma candidate genes CDKN2A/p16/INK4A, p14ARF, and CDK4 sequencing in patients with uveal melanoma with relative high-risk for hereditary cancer predisposition.
Melanoma research - 1 Jun 2011
Abdel-Rahman Mohamed H, Pilarski Robert, Massengill James B, Christopher Benjamin N, Noss Ryan, Davidorf Frederick H
Abstract excerpt
The reported frequencies of germline mutations in the melanoma candidate genes are low in patients with uveal melanoma (UM). However, the number of families studied is limited and the majority of the published reports used low-sensitivity techniques for mutational screening. Identifying the frequency of alterations in any of the melanoma genes in patients with UM with increased hereditary cancer risk is important...
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