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Article

Matrix metalloproteinase genes on chromosome 11q22 and the risk of anterior cruciate ligament (ACL) rupture.

Scandinavian journal of medicine & science in sports - 1 Aug 2012

Posthumus M, Collins M, van der Merwe L, O'Cuinneagain D, van der Merwe W, Ribbans W J, Schwellnus M P, Raleigh S M

Abstract excerpt

As matrix metalloproteinases (MMPs) are critical to ligament homeostasis and integrity, the aim of this study was to investigate whether four functional polymorphisms within four MMP genes, which cluster on chromosome 11q22 associate with risk of ACL ruptures. Three hundred and forty-five [129 with ACL ruptures (ACL group) and 216 asymptomatic controls (CON group)] unrelated Caucasians were recruited for this...

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Source

Identifiers

PMID: 21410539
DOI: 10.1111/j.1600-0838.2010.01270.x

Genes

MMP12
MMP1
MMP10
MMP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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