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Article

Genome-wide association analysis in dogs implicates 99 loci as risk variants for anterior cruciate ligament rupture.

PloS one - 1 Jan 2017

Baker Lauren A, Kirkpatrick Brian, Rosa Guilherme J M, Gianola Daniel, Valente Bruno, Sumner Julia P, Baltzer Wendy, Hao Zhengling, Binversie Emily E, Volstad Nicola, Piazza Alexander, Sample Susannah J, Muir Peter

Abstract excerpt

Anterior cruciate ligament (ACL) rupture is a common condition that can be devastating and life changing, particularly in young adults. A non-contact mechanism is typical. Second ACL ruptures through rupture of the contralateral ACL or rupture of a graft repair is also common. Risk of rupture is increased in females. ACL rupture is also common in dogs. Disease prevalence exceeds 5% in several dog breeds, ~100...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28379989
DOI: 10.1371/journal.pone.0173810
PMCID: PMC5381864

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