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Article

Investigating the Association of Genetic Markers, Previously Identified by Genome-Wide Association Studies, With ACL Rupture in Multiple Cohorts.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Sept 2026

Phipson Caryn, Laguette Mary-Jessica N, Cieszczyk Paweł, Ficek Krzysztof, Häger Charlotte K, Stattin Eva-Lena, Nilsson Kjell G, Feller Julian A, Tirosh Oren, September Alison V, Collins Malcolm

Abstract excerpt

Several direct-to-consumer genetic tests claim to predict susceptibility to anterior cruciate ligament (ACL) rupture. Although not independently replicated, polymorphisms identified in a genome-wide association study-rs144051132 (T > A), rs186727643 (C > T), and/or rs188099931 (A > G)-have been incorporated into commercial tests to estimate cruciate ligament injury risk. This study aimed to evaluate whether these...

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Topics

Adult
Female
Humans
Male
Young Adult
Anterior Cruciate Ligament Injuries
Cohort Studies
Genetic Markers
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Polymorphism, Single Nucleotide
Rupture
White People
Southern African People

Source

Open in PubMed Open full text

Identifiers

PMID: 42765509
DOI: 10.1002/jor.70282
PMCID: PMC13591651

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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