Biochemical transformation of canine skeletal muscle for use in cardiac-assist devices.

doi:10.1152/jappl.1990.68.4.1481

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Article

Biochemical transformation of canine skeletal muscle for use in cardiac-assist devices.

Journal of applied physiology (Bethesda, Md. : 1985) - 1 Apr 1990

Ianuzzo C D, Hamilton N, O'Brien P J, Desrosiers C, Chiu R

Abstract excerpt

Skeletal muscle has an inherent biochemical phenotypic plasticity that provides the possibility for it to be remodeled into a "heart-like" muscle for use in cardiac-assist devices. The purpose of this study was to chronically stimulate skeletal muscle electrically to transform the biochemical capacities of the three major subcellular systems (i.e., metabolic, calcium regulating, and contractile) to resemble those...

Topics

3-Hydroxyacyl CoA Dehydrogenases
Animals
Calcium
Calcium-Transporting ATPases
Citrate (si)-Synthase
Dogs
Electric Stimulation
Heart-Assist Devices
Homeostasis
Muscle Contraction
Muscles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myocardium

Myofibrils

Phenotype

Phosphofructokinase-1

Phosphorylases

Sarcoplasmic Reticulum

Source

Open in PubMed

Identifiers

PMID: 2140828
DOI: 10.1152/jappl.1990.68.4.1481

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2140828-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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