Article
Transcriptional regulation of phospholamban gene and translational regulation of SERCA2 gene produces coordinate expression of these two sarcoplasmic reticulum proteins during skeletal muscle phenotype switching.
The Journal of biological chemistry - 12 May 1995
Hu P, Yin C, Zhang K M, Wright L D, Nixon T E, Wechsler A S, Spratt J A, Briggs F N
Abstract excerpt
Chronic 1 Hz stimulation of the canine latissimus dorsi muscle produced a time-dependent switch from the fast-twitch to the slow-twitch phenotype. This included changes in the proteins of the sarcoplasmic reticulum. After 3 days of muscle stimulation, there was down-regulation of fast-twitch Ca-ATPase (SERCA1a) mRNA and induction of slow-twitch Ca-ATPase (SERCA2a) mRNA; most changes in both mRNAs were nearly...
Topics
- Adenosine Triphosphatases
- Animals
- Calcium-Binding Proteins
- Calcium-Transporting ATPases
- Conditioning, Psychological
- Dogs
- Electric Stimulation
- Gene Expression Regulation, Enzymologic
- Microsomes