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Article

Dichloroacetate selectively improves cardiac function and metabolism in female and male rainbow trout.

American journal of physiology. Heart and circulatory physiology - 15 Nov 2014

Battiprolu Pavan K, Rodnick Kenneth J

Abstract excerpt

Cardiac tissue from female rainbow trout demonstrates a sex-specific preference for exogenous glucose and glycolysis, impaired Ca(2+) handling, and a greater tolerance for hypoxia and reoxygenation than cardiac tissue from male rainbow trout. We tested the hypothesis that dichloroacetate (DCA), an activator of pyruvate dehydrogenase, enhances cardiac energy metabolism and Ca(2+) handling in female preparations...

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Source

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Identifiers

PMID: 25217653
DOI: 10.1152/ajpheart.00755.2013
PMCID: PMC4233302

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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