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Article

Genetic variation in SH3-domain GRB2-like (endophilin)-interacting protein 1 has a major impact on fat mass.

International journal of obesity (2005) - 1 Feb 2012

Cummings N, Shields K A, Curran J E, Bozaoglu K, Trevaskis J, Gluschenko K, Cai G, Comuzzie A G, Dyer T D, Walder K R, Zimmet P, Collier G R, Blangero J, Jowett J B M

Abstract excerpt

OBJECTIVE: The SH3-domain GRB2-like (endophilin)-interacting protein 1 (SGIP1) gene has been shown to be differentially expressed in the hypothalamus of lean versus obese Israeli sand rats (Psammomys obesus), and is suspected of having a role in regulating food intake. The purpose of this study was to assess the role of genetic variation in SGIP1 in human disease. SUBJECTS: We performed single-nucleotide...

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Source

Identifiers

PMID: 21407171
DOI: 10.1038/ijo.2011.67

Genes

SGIP1
GRB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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