Article
Genome-wide analysis identifies an african-specific variant in SEMA4D associated with body mass index.
Obesity (Silver Spring, Md.) - 1 Apr 2017
Chen Guanjie, Doumatey Ayo P, Zhou Jie, Lei Lin, Bentley Amy R, Tekola-Ayele Fasil, Adebamowo Sally N, Baker Jennifer L, Fasanmade Olufemi, Okafor Godfrey, Eghan Benjamin, Agyenim-Boateng Kofi, Amoah Albert, Adebamowo Clement, Acheampong Joseph, Johnson Thomas, Oli Johnnie, Shriner Daniel, Adeyemo Adebowale A, Rotimi Charles N
Abstract excerpt
OBJECTIVE: The prevalence of obesity varies between ethnic groups. No genome-wide association study (GWAS) for body mass index (BMI) has been conducted in continental Africans. METHODS: We performed a GWAS for BMI in 1,570 West Africans (WA). Replication was conducted in independent samples of WA (n = 1,411) and African Americans (AA) (n = 9,020). RESULTS: We identified a novel genome-wide significant...
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