Article
MC4R Variant rs17782313 Associates With Increased Levels of DNAJC27, Ghrelin, and Visfatin and Correlates With Obesity and Hypertension in a Kuwaiti Cohort.
Frontiers in endocrinology - 1 Jan 2020
Hammad Maha M, Abu-Farha Mohamed, Hebbar Prashantha, Cherian Preethi, Al Khairi Irina, Melhem Motasem, Alkayal Fadi, Alsmadi Osama, Thanaraj Thangavel Alphonse, Al-Mulla Fahd, Abubaker Jehad
Abstract excerpt
Melanocortin 4 receptor (MC4R), a notable component of the melanocortin system, regulates appetite, body weight, and energy homeostasis. Genome-wide association studies have identified several MC4R variants associated with adiposity; of these, rs17782313, which is associated with increased body mass index (BMI) and overeating behavior, is of particular interest. Another gene associated with increased adiposity in...
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