Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting Cell Cycle Facilitates E1A-Independent Adenoviral Replication.

Journal of virology - 29 Jun 2023

Ehrenfeld Maximilian, Segeth Felicia, Mantwill Klaus, Brockhaus Corinna, Zhao Yuling, Ploner Christian, Kolk Andreas, Gschwend Jürgen E, Nawroth Roman, Holm Per Sonne

Abstract excerpt

DNA replication of E1-deleted first-generation adenoviruses (AdV) in cultured cancer cells has been reported repeatedly and it was suggested that certain cellular proteins could functionally compensate for E1A, leading to the expression of the early region 2 (E2)-encoded proteins and subsequently virus replication. Referring to this, the observation was named E1A-like activity. In this study, we investigated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoviridae
Share to Adenovirus E1A Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Cycle

Share to DNA Replication

Share to Gene Expression Regulation, Viral

Share to Protein Kinase Inhibitors

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 37219458
DOI: 10.1128/jvi.00370-23
PMCID: PMC10308897

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting Cell Cycle Facilitates E1A-Independent Adenoviral Replication.PMID 37219458Read ↗

Human adenovirus type 5 vectors deleted of early region 1 (E1) undergo limited expression of early replicative E2 proteins and DNA replication in non-permissive cellsSemantic proximity Read ↗

Oncolytic adenovirus: A tool for cancer therapy in combination with other therapeutic approachesSemantic proximity Read ↗

Adenovirus and cell cycle controlSemantic proximity Read ↗

A comparative review of adenovirus A12 and C5 oncogenesSemantic proximity Read ↗

Adenovirus E1B55K Region Is Required To Enhance Cyclin E Expression for Efficient Viral DNA ReplicationSemantic proximity Read ↗

Evolving Horizons: Adenovirus Vectors’ Timeless Influence on Cancer, Gene Therapy and VaccinesSemantic proximity Read ↗

Designer Oncolytic Adenovirus: Coming of AgeSemantic proximity Read ↗

Adenovirus IVa2 protein plays an important role in transcription from the major late promoter in vivo.Semantic proximity Read ↗

Identification of a novel downstream binding protein implicated in late-phase-specific activation of the adenovirus major late promotor.Semantic proximity Read ↗

Adenovirus E1A Targets the DREF Nuclear Factor To Regulate Virus Gene Expression, DNA Replication, and GrowthSemantic proximity Read ↗

Oncolytic adenoviruses: design, generation, and experimental procedures.Semantic proximity Read ↗

Tumor-specific activation of hTERT-derived promoters by tumor suppressive E1A-mutants involves recruitment of p300/CBP/HAT and suppression of HDAC-1 and defines a combined tumor targeting and suppression system.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.