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Article

Creation of chimeric hearts: a tool for testing the "passenger leukocyte" hypothesis.

The Annals of thoracic surgery - 1 Sept 1997

Eiref S D, Zhang W, Popma S H, Shah L J, Moore J S, Rosengard B R

Abstract excerpt

BACKGROUND: Bone marrow-derived antigen-presenting cells (APCs) are thought to be a migratory component of organ allografts that activate the rejection response, and recently they have been postulated to play a critical role in tolerance induction. Our goal was to create chimeric hearts (organs with parenchyma and APCs of differing genotype) for use in models of transplantation to test the "passenger leukocyte"...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9307449
DOI: 10.1016/s0003-4975(97)00617-6

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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