Article
Creation of chimeric hearts: a tool for testing the "passenger leukocyte" hypothesis.
The Annals of thoracic surgery - 1 Sept 1997
Eiref S D, Zhang W, Popma S H, Shah L J, Moore J S, Rosengard B R
Abstract excerpt
BACKGROUND: Bone marrow-derived antigen-presenting cells (APCs) are thought to be a migratory component of organ allografts that activate the rejection response, and recently they have been postulated to play a critical role in tolerance induction. Our goal was to create chimeric hearts (organs w...
Topics
- Animals
- Antigen-Presenting Cells
- Bone Marrow
- Bone Marrow Transplantation
- Cause of Death
- Cell Movement
- Centrifugation, Density Gradient
- Chimera
- Collagenases
- Disease Models, Animal
- Flow Cytometry
- Fluoresceins
- Fluorescent Dyes
- Genotype
- Graft Rejection
- Graft Survival
- Histocompatibility Antigens Class II
- Immune Tolerance