Article
Donor blood monocytes but not T or B cells facilitate long-term allograft survival after total lymphoid irradiation.
Transplantation - 15 Sept 1998
Hayamizu K, Zeng D, Huie P, Garcia-Ojeda M E, Bloch D A, Fong L, Engleman E G, Sibley R K, Strober S
Abstract excerpt
BACKGROUND: Previous studies showed that a combination of posttransplant total lymphoid irradiation (TLI), rabbit antithymocyte globulin (ATG), and a single donor blood transfusion induced tolerance to ACI heart allografts in Lewis rats. All three modalities were required to achieve tolerance. Th...
Topics
- Animals
- Antilymphocyte Serum
- B-Lymphocytes
- Flow Cytometry
- Graft Survival
- Heart Transplantation
- Interferon-gamma
- Interleukin-2
- Interleukin-4
- Lymph Nodes
- Male
- Monocytes
- Phenotype
- Rabbits
- Rats
- Rats, Inbred Lew
- T-Lymphocytes
- Time Factors