Role of the transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic and functional-based study.

doi:10.1002/path.2816

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Article

Role of the transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic and functional-based study.

The Journal of pathology - 1 Feb 2011

Presneau Nadège, Shalaby Asem, Ye Hongtao, Pillay Nischalan, Halai Dina, Idowu Bernadine, Tirabosco Roberto, Whitwell Duncan, Jacques Thomas S, Kindblom Lars-Gunnar, Brüderlein Silke, Möller Peter, Leithner Andreas, Liegl Bernadette, Amary Fernanda M, Athanasou Nicholas N, Hogendoorn Pancras Cw, Mertens Fredrik, Szuhai Karoly, Flanagan Adrienne M

Abstract excerpt

A variety of analyses, including fluorescence in situ hybridization (FISH), quantitative PCR (qPCR) and array CGH (aCGH), have been performed on a series of chordomas from 181 patients. Twelve of 181 (7%) tumours displayed amplification of the T locus and an additional two cases showed focal amplification; 70/181 (39%) tumours were polysomic for chromosome 6, and 8/181 (4.5%) primary tumours showed a minor...

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PMID: 21171078
DOI: 10.1002/path.2816

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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