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Article

The cAMP responsive element modulator (CREM) transcription factor influences susceptibility to undernutrition and infection.

mBio - 13 Aug 2025

Brown Audrey C, Uddin Md Jashim, Munday Rebecca M, Naz Farha, Moreau G Brett, Ramakrishnan Girija, Rich Stephen S, Haque Rashidul, Wojcik Genevieve L, Duggal Priya, Marie Chelsea, Petri William A

Abstract excerpt

We previously identified genetic polymorphisms associated with Entamoeba histolytica-positive diarrhea at the locus containing the transcription factor, cAMP responsive element modulator (CREM). Genetic association testing in birth cohorts of Bangladeshi children showed the previously described single nucleotide polymorphisms (SNPs) at the CREM locus associated with E. histolytica-positive diarrhea were...

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PMID: 40576353
DOI: 10.1128/mbio.01390-25
PMCID: PMC12345263

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