Article
Mass spectrometry-based comparative sequencing to detect ganciclovir resistance in the UL97 gene of human cytomegalovirus.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 May 2011
Posthuma Clara C, van der Beek Martha T, van der Blij-de Brouwer Caroline S, van der Heiden Pim L J, Marijt Erik W A, Spaan Willy J M, Claas Eric C J, Nederstigt Christa, Vossen Ann C T M, Snijder Eric J, Kroes Aloys C M
Abstract excerpt
BACKGROUND: Persistent infections with herpesviruses such as human cytomegalovirus (HCMV) frequently occur after solid organ or stem cell transplantation, and are due to either failure of the host to immunologically control the virus or emerging resistance of the virus to the antiviral drug(s) used. Antiviral therapy can be guided by viral drug susceptibility testing based on screening for known...
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