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Mechanisms of oxysterol-induced carcinogenesis

9 Mar 2011

Abstract excerpt

Oxysterols are oxidation products of cholesterol that are generated by enzymatic reactions mediated by cytochrome P450 family enzymes or by non-enzymatic reactions involving reactive oxygen and nitrogen species. Oxysterols play various regulatory roles in normal cellular processes such as cholesterol homeostasis by acting as intermediates in cholesterol catabolism. Pathological effects of oxysterols have also...

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PMID: 21388551
DOI: 10.1186/1476-511x-10-44

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