Article
Both miR-17-5p and miR-20a alleviate suppressive potential of myeloid-derived suppressor cells by modulating STAT3 expression.
Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2011
Zhang Miaomiao, Liu Qiaofei, Mi Siping, Liang Xue, Zhang Zhiqian, Su Xiaomin, Liu Jinyi, Chen Yingying, Wang Mengmeng, Zhang Yuan, Guo Fenghua, Zhang Zhujun, Yang Rongcun
Abstract excerpt
Myeloid-derived suppressor cells (MDSCs) were one of the major components of the immune suppressive network. STAT3 has an important role in regulating the suppressive potential of MDSCs. In this study, we found that the expression of STAT3 could be modulated by both miR-17-5p and miR-20a. The transfection of miR-17-5p or miR-20a remarkably reduces the expression of reactive oxygen species and the production of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.