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Article

Aflatoxin genotoxicity is associated with a defective DNA damage response bypassing p53 activation.

Liver international : official journal of the International Association for the Study of the Liver - 1 Apr 2011

Gursoy-Yuzugullu Ozge, Yuzugullu Haluk, Yilmaz Mustafa, Ozturk Mehmet

Abstract excerpt

BACKGROUND: Hepatocellular carcinoma (HCC) is a leading cause of cancer deaths. Aflatoxins, which may play a causative role in 5-28% of HCCs worldwide, are activated in liver cells and induce principally G→T mutations, including the TP53 codon 249(G→T) hotspot mutation. The DNA damage checkpoint response acts as an antitumour mechanism against genotoxic agents, but its role in aflatoxin-induced DNA damage is...

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PMID: 21382167
DOI: 10.1111/j.1478-3231.2011.02474.x

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