Article
Origins and evolution of cell phenotypes in breast tumors.
Journal of theoretical biology - 7 Mar 2005
Tözeren Aydin, Coward Charles W, Petushi Sokol P
Abstract excerpt
This study presents a stochastic model that correlates genomic instability with tumor formation. The model describes the time- and space-variant volumetric concentrations of cancer cells of various phenotypes in a breast tumor. The cells of epithelial origin in the cancerous breast tissue are classified into four different phenotypes, normal epithelial cells and the grade 1, grade 2 and grade 3 cancer cell types...
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