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Article

Prediction of BRCA1 germline mutation status in women with ovarian cancer using morphology-based criteria: identification of a BRCA1 ovarian cancer phenotype.

The American journal of surgical pathology - 1 Aug 2012

Fujiwara Mika, McGuire Valerie A, Felberg Anna, Sieh Weiva, Whittemore Alice S, Longacre Teri A

Abstract excerpt

Specific morphologic features that may predict BRCA1 germline mutation in ovarian cancer have neither been well described nor independently tested. We identified 5 morphologic features associated with BRCA1 mutation status in a series of 20 ovarian cancers from BRCA1 mutation carriers: (1) modified Nottingham grade 3; (2) serous/undifferentiated histology; (3) prominent intraepithelial lymphocytes; (4) marked...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22790858
DOI: 10.1097/PAS.0b013e31825d9b8d
PMCID: PMC3422129

Genes

BRCA1

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