Pathology of ovarian cancers in BRCA1 and BRCA2 carriers.

doi:10.1158/1078-0432.ccr-1029-3

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Article

Pathology of ovarian cancers in BRCA1 and BRCA2 carriers.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2004

Lakhani Sunil R, Manek Sanjiv, Penault-Llorca Frederique, Flanagan Adrienne, Arnout Laurent, Merrett Samantha, McGuffog Lesley, Steele Dawn, Devilee Peter, Klijn Jan G M, Meijers-Heijboer Hanne, Radice Paolo, Pilotti Silvana, Nevanlinna Heli, Butzow Ralf, Sobol Hagay, Jacquemier Jocylyne, Lyonet Dominique Stoppa, Neuhausen Susan L, Weber Barbara, Wagner Teresa, Winqvist Robert, Bignon Yves-Jean, Monti Franco, Schmitt Fernando, Lenoir Gilbert, Seitz Susanne, Hamman Ute, Pharoah Paul, Lane Geoff, Ponder Bruce, Bishop D Timothy, Easton Douglas F

Abstract excerpt

PURPOSE: Germline mutations in the BRCA1 and BRCA2 genes confer increased susceptibility to ovarian cancer. There is evidence that tumors in carriers may exhibit a distinct distribution of pathological features, but previous studies on the pathology of such tumors have been small. Our aim was to evaluate the morphologies and immunophenotypes in a large cohort of patients with familial ovarian cancer. EXPERIMENTAL...

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Identifiers

PMID: 15073127
DOI: 10.1158/1078-0432.ccr-1029-3

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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