Article
Localization of SMAP2 to the TGN and its function in the regulation of TGN protein transport.
Cell structure and function - 1 Jan 2011
Funaki Tomo, Kon Shunsuke, Ronn Roger E, Henmi Yuji, Kobayashi Yuka, Watanabe Toshio, Nakayama Keiko, Tanabe Kenji, Satake Masanobu
Abstract excerpt
SMAP2 is an Arf GTPase-activating protein that is located and functions on early endosome membranes. In the present study, the trans-Golgi network (TGN) was verified as an additional site of SMAP2 localization based on its co-localization with various TGN-marker proteins. Mutation of specific stretches of basic amino acid residues abolished the TGN-localization of SMAP2. Over-expression of wild-type SMAP2, but...
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